Interim Clinical Considerations for Use of COVID-19 Vaccines in the United States

At a glance

  • These clinical considerations inform healthcare professionals and public health officials on use of COVID-19 vaccines.
  • The Table of Contents on each page can be used to navigate to all guidance pages.
  • A PDF version of the complete clinical considerations is available below to download and print.

Summary of recent changes

Last updated May 1, 2025

  • The Interim Clinical Considerations have been divided into multiple pages by guidance topic to enhance usability.
  • Vaccination guidance and schedules are unchanged; some text has been reformatted and reorganized.

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Interim Clinical Considerations for Use of COVID-19 Vaccines in the United States (May 1, 2025)

Implementation resources

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Content Source:
National Center for Immunization and Respiratory Diseases; Coronavirus and Other Respiratory Viruses Division