Case Definitions: Age-Related Macular Degeneration (AMD) Treatment

What to know

  • VEHSS includes indicators on the percentage of people with diagnosed AMD who had a treatment claim from payment claims in administrative claims databases and medical record information in the IRIS Registry of electronic health records.
  • VEHSS reports the percent of patients diagnosed with AMD who received at least one included treatment during the year of observation.
  • Therefore, all prevalence estimates are based on a denominator of patients who had a visit during the calendar year that included an AMD diagnosis.
Eye doctor sticking needle in patients eye

Anti–vascular endothelial growth factor (Anti-VEGF) injection

Anti-VEGF injection procedures are identified among patients with diagnosed AMD based on the procedure, diagnosis, and national drug codes (NDC) listed below.

Included Procedures

Procedure Codes

Aflibercept (Eylea®)

Any of (J0177, J0178, C9161) or J9400 with primary diagnosis of AMD or CPT 67028 on same claim

Brolucizumab

J0179

Bevacizumab (Mvasi®, Zirabev®, Alymsys®)

Any of (C9257, J9035, Q5107, Q5118, C9142, Q5126 ) with primary diagnosis of AMD or CPT 67028 on same claim

Faricimab (Vabysmo®)

J2777

Pegaptanib sodium (Macugen®)

J2503

Ranibizumab (Lucentis®, Susvimo®, Byooviz®)

Any of (J2778, J2779, C9093, Q5124) or Q5128 with primary diagnosis of AMD or CPT 67028 on same claim

Unclassified injectable or compounded drug

Any of (J3490, J3590, J7999, Q9977) with primary diagnosis of AMD or CPT 67028 on same claim

Explore Data in the VEHSS Application

The data sources available for this category include Medicare (default), IRIS Registry, Medicaid, Managed Vision Care, and MarketScan commercial insurance claims.

Laser/photocoagulation therapy

Laser/photocoagulation therapy procedures are identified among patients with diagnosed AMD based on the procedure and diagnosis codes listed below.

  • Included Procedures - Destruction procedures on the retina or choroid, photocoagulation
  • Procedure Codes - 67220 or G0186

The data sources available for this category include Medicare (default), IRIS Registry, Medicaid, Managed Vision Care, and MarketScan commercial insurance claims.

Explore Data in the VEHSS Application

The data sources available for this category include Medicare (default), IRIS Registry, Medicaid, Managed Vision Care, and MarketScan commercial insurance claims.

Photodynamic therapy

Photodynamic therapy procedures are identified among patients with diagnosed AMD based on the procedure and diagnosis codes listed below.

Included Procedures

Procedure Codes

Destruction procedures on the retina or choroid, photodynamic therapy

67221

Destruction procedures on the retina or choroid, photodynamic therapy, second eye

67225

Verteporfin injection

J3396

Explore Data in the VEHSS Application

The data sources available for this category include Medicare (default), IRIS Registry, Medicaid, Managed Vision Care, and MarketScan commercial insurance claims.